The expression of Trem-1 in the patients with endometriosis
Objectives Trem-1 (triggering receptor expressed on myeloid cells)-1 is one member of the novel receptors of Ig superfamily. In this study, we investigated the roles of Trem-1 in the pathogenesis of endometriosis (EMS). Methods The level of sTrem-1 were measured by ELISA in women with or without EMS, and the expression of Trem-1 mRNA in the peripheral leucocytes in 6 cases of women with EMS and 6 cases of women without EMS using real-time RT-PCR. And the expression of Trem-1 in the ectopic endometrium of women with endometriosis was analysed with immunohistochemistry. Results There were significant differences in sTrem-1 levels in peritoneal fluid and serum between EMS patients and control (P<0.01). The expressions of Trem-1 mRNA in the women with and without EMS were 0.765±0.022 and 0.695±0.035, respectively. There was also significant difference between the two groups (P<0.05). But, there was not expression of Trem-1 in the ectopic endometrium. Conclusion The expression of Trem-1 in women with EMS was up-regulated, suggesting that Trem-1 might play an important role in the occurrence and development of EMS.
Ruyun Qian Yugui Cui Wei Wang Yundong Mao Jiayin Liu
Center of Clinical Reproductive Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China
国际会议
The 5th International Forum on Post-genome Technologies(5IFPT)(第五届国际后基因组生命科学技术学术论坛)
苏州
英文
2007-09-10（万方平台首次上网日期，不代表论文的发表时间）