Telomerase Restrictors Might be A Novel Source for Screening Anti-HIV Agents

摘要：

Objectives: to screen anti-HIV agents from telomerase restrictors(TRs); Method: Selection of the maximum concentration of telomerase restrictor with minimum toxicity by means of MTT proliferation determination, and screening of anti-HIV agents by means of determining CEM-GFP fluorescence with FACS and through INNOTEST P24 HIV Antigen mAb ELISA. Results: Two telomerase restrictors were demonstrated to effectively restrict the proliferation of HIV. Conclusion: Telomerase restrictors(TR) might be the source for screening anti-HIV agents.

关键词： Telomerase Telomerase Restrictors HIV Anti-HIV Agents Screening

作者: Xin Yu Jinghui Wang Carlo De Giuli Morghen Antonia Radaelli Carlo Zanotto Paola Beggio

作者单位: College of Pharmacy Wuhan University Wuhan 430072 P.R.China Department of Medical Pharmacology University of Milan Via Vanvitelli 32, 20129 Milano, Italy

会议类型: 国际会议

会议名称: The 1st International Conference on Bioinformatics and Biomedical Engineering(iCBBE 2007)(首届IEEE生物信息与生物医学工程国际会议)

会议地点: 武汉

会议语种:英文

页码: 88-91

在线出版日期: 2007-07-06（万方平台首次上网日期，不代表论文的发表时间）