A Populations Evolution Study Using the Genotype Frequency Data of Single Nucleotide Polymorphism from Y-Chromosome

摘要：

This paper proposes a novel way for the population evolution research. In the paper, it constructs the phylogenies tree of four populations using the single nucleotide polymorphism (SNP) genotype frequency of humans Ychromosome provided by the international Hapmap project firstly, then a mathematical model is proposed to calculate the distance of any two races for all SNP genotype frequeucy. The simulation results suggest that the theory of constructing phylogenetic tree by analyzing SNP genotype frequency is effective. The accuracy of the adopted processing method is also shown by the simulation results. About the origination of modern Africa hypothesis, and this result is same as most evidences of paleontology.

关键词： Populations evolution Y-chromosome Single nucleotide polymorphism Genotype frequency data Phylogenies tree

作者: Zhili Pei Ying Kong Xiaohu Shi Zhichao Lian Xuning Tang Lisha Liu Zhongbo Cao Yanchun Liang

作者单位: College of Computer Science and Technology, Jilin University, Key Laboratory of Symbol Computation a Department of Biochemistry and Molecular Biology, Institution of Glycobiology, Dalian Medical Univer College of Computer Science and Technology, Jilin University, Key Laboratory of Symbol Computation a

会议类型: 国际会议

会议名称: The 1st International Conference on Bioinformatics and Biomedical Engineering(iCBBE 2007)(首届IEEE生物信息与生物医学工程国际会议)

会议地点: 武汉

会议语种:英文

页码: 294-297

在线出版日期: 2007-07-06（万方平台首次上网日期，不代表论文的发表时间）