Protective effects of soft ripened cheese (camembert) containing vegetable oil (rapeseed) compared to classical dairy fat cheese on the severity of atherogenic markers in hamsters fed hyperlipidemic diets
Milk fat is rich in saturated fatty acids (SFA) known to increase plasma cholesterol, but we previously showed that there was some benefit to cheese consumption compared to milkfat: at equal fat content, cheese was less atherogenic than milkfat*. In this study we evaluated the impact of diets including cheese prepared with different fat sources: Veg-cam cheese Primevere prepared with vegetable rapeseed oil (poor in SFA) compared to Dairy-cam cheese prepared with milkfat (camembert) rich in SFA and cholesterol.Two groups of 9 hamsters were fed with equal fat and protein contents from cheese sources: Dairy-cam or Veg-cam. Diets were obtained by blending lyophilized whole cheese with the chow-based diet, to provide up to 10％ or 20％ (by weight) of fat.Animals were fed for 5wks with the 10％ fat diets and then with the 20％ fat diets till 17wks. The atherogenic impact was evaluated after both 10％ and 20％ fat diets on plasma iipids: total cholesterol (TC), LDLC, non-HDLC, atherogenic ratio non-HDLC/HDLC, and after the 20％ fat diets by measuring the aorta lesions severity expressed by its cholesteryl esters (CE)content (by GLC).Results showed that after the 10％ fat diets, Veg-cam induced lower levels of plasma lipids than Dairy-cam (TC:- 29％ p＜0.001, non-HDL/HDLC:-45％p＜0.05). Interestingly, the increase of fat intake from 10％ to 20％ induced opposite changes in plasma lipids: a decrease with Veg-cam (TC:-16％ p＜0.001), and an increase with Dairy-cam (TC:+20％ p＜0.05), resulting in much more prominent differences after the long term 20％ fat diets (TC:- 51％p＜0.001). However, the increase of fat intake from 10％ to 20％ did not modified the plasma atherogenic ratio non-HDLC/HDLC within each type of cheese diet: Veg-cam ratio (0.56vs0.56) and Dairy-cam ratio (1.06vs113). The atherosclerotic fatty streaks evaluated by the CE levels of the aortas were also dramatically reduced: four time less in Veg-cam group than in the Dairy-cam group.At equal fat and protein content, cheese prepared with rapeseed vegetal oil is less atherogenic than the classical dairy cheese and may contribute to the recommended SFA reduction intake. *B. Delplanque, A. Thaminy, G. Agnani, JC. Martin, K. Bensharif,D Gripois. Comparison of the effects of cheese or butter on the severity of atherogenic markers in hamsters fed an hyperlipidemic diet. ISA 2006 Rome
Rapeseed oil cheese saturated unsaturated alphalinolenic fatty acids plasma and aorta lipids
Bernadette Delplanque Genevieve Agnani Anissa Thaminy Jean-charles Martin Karima Bensharif Daniel Gripois
NMPA, Universite-ParisXI, Orsay, France UMR Lipides Nutrition Humaine, Marseille, Fr.With grants from LACTALIS
国际会议
第十二届国际油菜大会( The 12th International Rapeseed Congress)
武汉
英文
1783-1784
2007-03-26（万方平台首次上网日期，不代表论文的发表时间）