Classical swine fever vaccinology: factors critical for successful vaccination in endemic areas
Classical swine fever (CSF), caused by the classical swine fever virus (CSFV), is one of the most important viral diseases that cause serious economic loss to the swine industry worldwide including the Asian countries. This paper discusses recent knowledge of immunological mechanisms underlying vaccine-induced protective immunity and factors critical for successful immunization against CSFV in endemic areas. Information, obtained from our series of experiments in Thailand, demonstrate that cell-mediated immunity plays crucial role in protective immunity against CSF infection, and that the modified live CSF vaccines are able to induce complete heterotypic protection against the CSFV. Nevertheless, several factors including maternal-derived immunity, the age at primary vaccination, vaccination protocol and complications caused by other pathogens, particularly porcine reproductive and respiratory syndrome virus (PRRSV) infection, can greatly affect the effectiveness of CSF vaccines in the field. The findings highlight the significance of routine serosurveillance and the use of other diagnostic tools for monitoring the herd immune status and planning of immunoprophylaxis.
Classical swine fever vaccination cell-mediated immunity PRRSV
Sanipa Suradhat
Department of Veterinary Microbiology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, Thailand
国际会议
亚洲猪病学会第三届学术会议(Proceedings the 3rd Congress of the Asian Pig Veterinary Society)
武汉
英文
43-49
2007-04-22（万方平台首次上网日期，不代表论文的发表时间）