The levels of lycopene, α-tocopherol and a marker of oxidative stress in healthy northeast Thai elderly
(0) An imbalance between oxidative stress and antioxidant capacity has been proposed to play an important role in the development and progression of chronic diseases in the elderly. The present study was carried out to investigate correlation between the serum antioxidants (lycopene and α-tocopherol) and malondialdehyde (MDA), a marker of oxidative stress in the healthy Thai elderly. The 207 healthy subjects aged 60-91 years old (72 males and 135 females) in Khon Kaen province, Thailand were enrolled in this study. They were interviewed by questionnaires about smoking habit. Serum lycopene and α-tocopherol levels were determined by high performance liquid chromatography (HPLC). MDA was measured by thiobarbituric assay. Serum lycopene and α-tocopherol levels in the elderly were 0.27 μmol/L (95％ CI =0.23-0.31) and 22.10 μmol/L (95％ CI =20.99-23.22), respectively. Males had significant lower serum lycopene and α-tocopherol levels than females (p＜0.01). Of 72 males,31.94％ are current smokers whereas 1.4％ of 135 females are current smokers. Current smokers had significantly lower serum lycopene (0.17 ± 0.11 μmol/L) than current non-smokers (0.28 ± 0.27 μmol/L) (p=0.04) but level of α-tocopherol had non significance (p=0.21). Moreover, the current smokers had higher malondialdehyde level (1.55 ± 0.10 μmol/L) than the current non-smokers (1.35 ± 0.04 μmol/L) (p=0.09). Thus, dietary antioxidant supplementation from local fruits and vegetables may have a beneficial role in the prevention of chronic diseases at high-risk oxidative stress such as smoking in these elderly.
lycopene α-tocopherol oxidative stress smoking northeast Thais
Prasit Suwannalert Patcharee Boonsiri Tueanjit Khampitak Kovit Khampitak Pote Sriboonlue Puangrat Yongvanit
Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand Department of Obstetrics and Gynecology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002,
国际会议
国际营养科学联盟第八届临床营养学大会暨第五届亚太临床营养学会大会
杭州
英文
27-30
2006-10-01（万方平台首次上网日期，不代表论文的发表时间）