Effects of soybean isoflavone dosage and exercise on the serum markers of bone metabolism in ovariectomized rats
This study was designed to determine whether combined treatments with soybean isoflavone dosage and moderate exercise would exhibit synergistically effects on bone metabolism following the onset of menopause. Fifty 12 wk-old female Wistar rats were assigned to five groups: 1) Sham operated (Sham), 2) ovariectomized (OVX), 3) OVX received soybean isoflavone (OVX-IF), 4) OVX exercised (OVX-EXE) and 5) OVX treated with both soybean isoflavone and exercise (OVX-IF-EXE). All rats were fed a normal diet ad libitum. Daily soybean isoflavone dosage was 50 mg/kg body weight. The vehicle was given in Sham, OVX and OVX-EXE groups.The drugs were all oral administered using a stomach tube. Exercising rats were trained on an uphill treadmill at 20 m/min for 1h/day, 5days/week. The experimental duration consisted of the adaptation periods of 2 weeks and treatment periods of 8 weeks. The results showed that the uterus relative weights in OVX-EXE, OVX-IF and OVX-IF-EXE groups were all lower than those in Sham, they were higher than those in the OVX group. Serum alkaline phosphates (AKP) activitie of OVX was significantly increased as compared to that of Sham (p＜0.01).OVX-IF and OVX-IF-EXE respectively decreased the Serum alkaline phosphates activities, as compared to that of OVX (p＜0.01). The tartrate-resistant acid phosphatase (TRAP) value of OVX was significantly increased as compared to that of Sham (p＜0.05). OVX-IF decreased the TRAP as compared to that of OVX (p＜0.05). These results suggest soybean isoflavone and resistance exercise both can restrain ovx-induced bone loss. But their mechanisms may be different.
ovariectomized rats soy isoflavone exercise bone mineral density
Kemin Liu Yanhuan Liu Zhenyu Liu Guodong Ma Guofeng Lv Yuan Zou Wencheng Wang Lihong Liu Ping Yan Yanna Liu Lijie Jiang
Department of Sports Medicine, Dalian Medical University, Dalian, China Department of Physical education, Shandong University of Technology, Shandong, China Department of Exercise Science, Tianjin Institute of Physical Education, Tianjin, China Infirmary of Beihua University, Jilin, China
国际会议
国际营养科学联盟第八届临床营养学大会暨第五届亚太临床营养学会大会
杭州
英文
193-195
2006-10-01（万方平台首次上网日期，不代表论文的发表时间）