Immunomodulatory activity of aqueous extract of Actinidia macrosperma
Actinidia macrosperma (AM) is a medicinal plant in China and has been well known for its activities against cancers, especially of lung, liver and digestive system. The immunomodulatory effects of AM aqueous extract were examined using S180-bearing mice. Young adult (20 ± 2 g) ICR mice inoculated with S180 cells were divided randomly into six groups: S180-bearing control group, normal control group, positive control group (Ginseng Radix Rubra 2000 mg/kg) and 50, 100, 250 mg/kg AM treatment groups. Each group consisted of ten mice.Body and tumor weights were obtained after 12 consecutive days, and their humoral, cellular and nonspecific immune functions were also determined by relative assays. The results showed that the aqueous extract of AM was lack of significant inhibit on transplantable sarcoma S180, with a inhibit rate of 1.5％-14.8％ (dose at 250 mg/kg was the best), but significantly increased the overall immune functions (especially at 100 and 250 mg/kg).The immunomodulatory effect was dose-dependent in a nonlinear fashion with the optimal dose of 100 mg/kg.The AM-induced antitumor effects were at least partially indirect and were associated with the modulation of immune functions.
antitumor immunomodulator Sarcoma-180 (S180) Actinidia macrosperma
Yin Lu Jie Fan Yunpeng Zhao Shaoyuan Chen Xiaodong Zheng Yuanming Yin Chengxin Fu
Research Program of Natural Products and Phytochemistry, Lab of Systematic & Evolutionary Botany and College of Biosystems Engineering and Food Sciences, Zhejiang University, Hangzhou, China
国际会议
国际营养科学联盟第八届临床营养学大会暨第五届亚太临床营养学会大会
杭州
英文
261-265
2006-10-01（万方平台首次上网日期，不代表论文的发表时间）