Hypolipidemic effect of flavonoids from mulberry leaves in triton WR-1339 induced hyperlipidemic mice
The aim of this study was to investigate the hypolipidemic effect of the total flavonoids from mulberry leaves (MTF) in hyperlipidemic mice. The total flavonoids have been isolated from mulberry (Morus alba L.) leaves and purified by macroporous resins. After that, the content of MTF is 581.7 mg g-1 in dried product. The hypolipidemic effect of MTF has been evaluated in triton WR-1339 (400 mg kg-1) induced hyperlipidemic mice. The beneficial effects of MTF on serum lipid levels are more significant at 12h post MTF administration than at 6h.The levels ofTG, TC and LDL-C were remarkably reduced to 388, 257 and 189 mg 100 ml-1 in MTF (30 mg kg-1) and triton WR-1339 treated mice, compared with 540, 464 and 299 mg 100 ml-1, respectively, in group treated by triton WR-1339 only. The ratios of HDL-C/rC and HDL-C/LDL-C were increased to 0.42 and 0.57 post MTF (30 mg kg-1) administration, whereas these two ratios at the low levels of 0.33 and 0.52, respectively, in the reference group. These findings support a serum a lipid-favourable activity for mulberry leaf flavonoids.
flavonoid Morus Mba L. hypolipidemic activity triton WR-1339
Jingjing Chen Xiangrong Li
College of Pharmaceutical Science, Zhejiang University, Hangzhou, China;SFFT Developing Co.Ltd., Han Faculty of Life Science, City College, Zhejiang University, Hangzhou, China
国际会议
国际营养科学联盟第八届临床营养学大会暨第五届亚太临床营养学会大会
杭州
英文
290-294
2006-10-01（万方平台首次上网日期，不代表论文的发表时间）