The oxidative Mechanism of Cataract Induced by UV Irradation and its Inhibition by Natural Products
Cataract accounts for more than 40 million cases of visual impairment and is the main cause of human blindness in China. UV- irradiation is one of the important factors that can induce cataract in human eyes. After lens proteins were exposed to UV-irradiation ranging from 200 to 400 nm wavelength, fluorescence absorbance of tryptophan, the low molecular weight (LMW) proteins decreased, while that of the light-sensitive material, N-formyl-kynurenine (NFK) increased. During the same irradiation process, the lens proteins kept on cross-linking and polymerizing, and the ratio of high molecular weight (HMW) proteins increased. Since UV irradiation also could produce free radicals, which could cause damages to the lens, as a result, the lens became cloudy and cataract was formed. The production of free radical from lens protein after UV-irradiation indicates that UV-irradiation damage to lens induced by the free radical oxidative mechanism. Some natural products such as Se-containing polysaccharide (Se-GPS) isolated from Se-rich garlic and Flavornoids extracted from Ginkgo biloba L.(F-EGb) possess protective effects on lens protein against oxidative damage induced by UV-irradiation. Therefore, the study could potentially shed some light on the discovery of medications to treat UV-irradiation-induced cataract.
UV-irradiation Lens Cataract
Yang Ming Wang Wen Xiao Sulong
The State Key Research Laboratories of Natural and Biomimetic Drugs, Peking University Health Scienc Department of Pharmacology, Xuan-Wu Hospital of Capital University of Medical Sciences, Beijing 1000
国际会议
26th Session of the CIE(国际照明委员会（CIE）第26届大会)
北京
英文
1033-1036
2007-07-04（万方平台首次上网日期，不代表论文的发表时间）