INITIATION AND DOSE CONCENTRATION OF HTV CONTROL
In this paper, we propose to initiate the HIV therapy based on the Lyapunov exponents of the system. If one of the Lyapunov exponents of the system is positive, then the therapy is initiated, and the control is deactivated vice versa. The dose concentration (when the therapy is initiated) is determined based on a control law in which it is formulated according to the Lyapunov stability criterion. Numerical simulation results show that the controlled viral load is decreasing and all physical constraints of the system, such as the boundedness and the positivity of all state variables and the dose concentration, are satisfied.
Charlotte Yuk-Fan Ho Bingo Wing-Kuen Ling H.K.Lam
Dept.of Electronic Engineering and School of Mathematical Sciences, Queen Mary, University of London Dept.of Electronic Engineering, Division of Engineering, Kings College London, Strand,London, WC2R Dept.of Electronic Engineering,Division of Engineering, Kings College,London, Strand, London, WC2R
国际会议
杭州
英文
160-163
2007-06-06（万方平台首次上网日期，不代表论文的发表时间）