Patient-Specific Virtual Surgery for Right Ventricle Volume Reduction and Patch Design Using MRI-Based 3D FSI RV/LV/Patch Models
Right ventricular (RV) dysfunction is a common cause of heart failure in patients with congenital heart defects and often leads to impaired functional capacity and premature death. A novel surgical/modeling procedure is proposed to test the hypotheses that a) patient-specific image-based computational modeling can provide accurate information for assessment of RV function and that b) more aggressive scar removal using computer-aided surgery design with optimized post-operative RV morphology and patch design will lead to improved recovery of RV functions. Cardiac Magnetic Resonance (CMR) Imaging studies were performed in a dedicated MRI suite located in the Department of Cardiology at Childrens Hospital Boston to acquire patient-specific ventricle geometry, heart motion, flow velocity, and flow rate for patients needing RV remodeling and pulmonary valve replacement operations before and after scheduled surgeries and healthy volunteers. MRI-based RV/LV combination models with fluidstructure interaction (FSI), RV-LV interaction, and RV-patch interaction were introduced to perform mechanical analysis and assess RV cardiac functions. The patient-specific FSI model (validated by pre-operation data) was used to predict possible outcome of virtual surgeries (i.e., with modified RV morphologies) and good agreement between computational predictions and pre-post operation RV stroke volume and ejection ratio as measured by CMR was found.
right ventricle congenital heart disease tetralogy of fallot heart model fluid-structure interaction.
Dalin Tang Chun Yang Tal Geva Pedro J.del Nido
Mathematical Sciences Department Worcester Polytechnic Institute Worcester, MA 01609, USA Mathematics Department, Beijing Normal University, Beijing, China Department of Cardiology, Childrens Hospital, Boston Department of Pediatric, Harvard Medical Schoo Dept. of Cardiac Surgery, Childrens Hospital, Boston Harvard Medical School, Boston, MA 02115 USA
国际会议
北京
英文
158-163
2007-05-23（万方平台首次上网日期，不代表论文的发表时间）