Biodegradable Polylactide Microspheres Containing Anticancer Drugs Used as Injectable Drug Delivery System
Biodegradable poly(lactic-acid) (PLA ) microspheres containing 5-fluorouracil were prepared by a solid in oil in water emulsion solvent evaporation method. The influences of various preparation parameters, such as polymer concentration, polymer molecular weight, oil-phase volume and PVA concentration in the external water phase on the characteristics of the microspheres and drug release profiles , the in vitro cell inhibition were investigated .It was found that the particle size was 100.25 ±2.50 μm and the drug loading was 8.25％(w/w). The in vitro release profiles of 5-fluorouracil loaded microspheres showed an initial burst release and thereafter the release was relatively slow. The in vitro cell inhibition indicate that the activity of 5-Fu is not weakened during the microshperes fabrication process and the solvent evaporation method is a mild fabrication technique for keeping drug stability.
polylactide microspheres in vitro release profiles in vitro cell inhibition
Tingying Cao Xiangdong Gao Yueqing Gu
Department of Biomedical Engineering, School of Life Science and Technology, China Pharmaceutical University ,Nanjing 210009 CHINA
国际会议
北京
英文
227-230
2007-05-23（万方平台首次上网日期，不代表论文的发表时间）