Focal cerebral Ischemia in Rats by Photothrombosis of Cortical Microvessels

摘要：

Among the available animal models of brain ischemia, it is broadly considered that cerebral cortex microvessels thrombosis induced by photochemical method is similar to human cerebral thrombosis. The brain tissues are damaged by the lack of blood and oxygen induced by thrombosis of the microvessels region. In this study, optical intrinsic signal imaging (OISI, at 546 ± 10nm) was used to investigate the evolution of a photothrombotic lesion to somatosensory cortex. During illumination, we observed clots flow several times in illuminated region vessels, and vessels turned vague, which indicated occlusion is forming. The result of TTC staining shows that the illuminated area was infarct.

作者: Xiaolu Deng Fayi Liu Yucheng Wang Ming Li Yadong Liu Dewen Hu

作者单位: Neurophysiology Department, Xiangya Medical College of Center South University, Hunan Changsha, 4100 College of Mechatronics and Automation, National University of Defense Technology, Hunan Changsha, 4

会议类型: 国际会议

会议名称: 2007 IEEE/ICME International Conference on Complex Medical Engineering-CME2007(CME2007 第二届国际复合医学工程学术大会)

会议地点: 北京

会议语种:英文

页码: 500-503

在线出版日期: 2007-05-23（万方平台首次上网日期，不代表论文的发表时间）