Quantifying Human Atherosclerotic Plaque Growth Function Using Multi-Year in Vivo MRI and Meshless Local Petrov-Galerkin Method

摘要：

Atherosclerosis is a disease in human circulation system affecting a large percentage of people,especially elderly people in the developed countries.To better predict plaque progression and prevent potential rupture,multi-year MRI patient-tracking data were obtained to quantify human atherosclerotic plaque progression.MRI-based 2D/3D models with multi-component plaque structure and fluid-structure interactions (FSI)were developed and solved by numerical methods based on the meshless local Petrov-Galerkin (MLPG) method (2D)and finite element method (2D/3D)to quantify plaque growth functions which can be used to simulate plaque progression for early prediction and diagnosis of atherosclerosisrelated cardiovascular diseases.For the first time,quantitative human plaque growth functions were determined using structure stress and flow shear stress data.Use of multi-year data leads to verifiable simulations and improved accuracy of predictions.Our initial results support the new hypothesis that plaque progression has negative correlation with structural stress and flow shear stress conditions.Plaque growth functions using both structure stress and flow shear stress leads to much better agreement with patient plaque progression data than using either of them.More data and validations are needed to confirm our findings.

关键词： Atherosclerosis carotid artery plaque progression blood flow meshless method fluid-structure interaction.

作者: Dalin Tang Chun Yang Joseph D.Petruccelli Chun Yuan Fei Liu Tom Hatsukami Sayan Mondal Satya Atluri

作者单位: Mathematical Sciences Department Worcester Polytechnic Institute Worcester,MA 01609,USA Mathematics Department,Beijing Normal University,Beijing,China Deparment of Radiology,University of Washington Seattle,WA 98195 USA Division of Vascular Surgery,University of Washington,Seattle,WA.98195 USA Center for Aerospace Research &Education,University of California,Irvine Irvine,CA 92612 USA

会议类型: 国际会议

会议名称: 2007 IEEE/ICME International Conference on Complex Medical Engineering-CME2007(CME2007 第二届国际复合医学工程学术大会)

会议地点: 北京

会议语种:英文

页码: 541-546

在线出版日期: 2007-05-23（万方平台首次上网日期，不代表论文的发表时间）