Implication of Output Signal from Optical Topography and fMRI
Non-invasive neuroimaging techniques can be divided into the following three categories judging from the property of their measured parameters: 1) magneto-encephalography (MEG) and electroencephalography (EEG), which measure direct neural activity, 2) magnetic resonance spectroscopy (MRS) and positron emission tomography (PET), which measure metabolic activity, and 3) functional magnetic resonance imaging (fMRI) and near infrared spectroscopy (fNIRS), which measure hemodynamic responses accompanied with neural activation. When we use these techniques, we implicitly assume that there are tight coupling between those physiological parameters. However, fMRI and fNIRS inevitably include responses from respiratory and autonomic nerve systems as artifacts. Therefore, it is required to elucidate whether and howsignals obtained by fMRI and fNIRS reflect neural activity accompanied with stimulus-induced brain activation. In this paper, we report one of experimental approaches using animal and humansubjects.
neuroimaging fMRI fNIRS hemodynamic response neurovascular coupling response function.
Akitoshi Seiyama Yasuhiro Ooi Junji Seki
High Performance Bioimaging Research Facility, Graduate School of Frontier Biosciences, Osaka Univer Division of Pathogenesis and Control of Oral Disease, Osaka University Graduate School of Dentistry, Department of Biomedical Engineering, National Cardiovascular Center Research Institute, Japan;JST-C
国际会议
北京
英文
952-954
2007-05-23（万方平台首次上网日期，不代表论文的发表时间）