High Resolution and High Contrast Noninvasive Photoacoustic Imaging of Neovascularization in Tumor Angiogenesis
Photoacoustic tomography (PAT) was presented to in vivo monitor neovascularization in tumor angiogenesis with high resolution and high contrast images in a rat. With a circular scan system, the photoacoustic signal, generated by laser pulses at a wavelength of 532 nm from a Q-switched Nd:YAG laser, is captured through of a hydrophone with a diameter of 1 mm and a sensitivity of 850 nV/Pa. The vascular structure around the rat tumor was imaged clearly, with optimal contrast, because blood has strong absorption near this wavelength. Serial noninvasive photoacoustic images of neovascularization in tumor angiogenesis were also obtained consecutively from a growing tumor implanted under the skin of a rat over a period of two weeks. This work demonstrates that PAT can potentially provide a powerful tool for tumor angiogenesis detection in cancer research. It will bring us closer to clinical application of the technique for tumor diagnosis and treatment monitoring.
Liangzhong Xiang Da Xing Huaimin Gu Diwu Yang Sihua Yang Lvming Zeng
MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, South China Normal University, Guangzhou 510631, China
国际会议
北京
英文
985-989
2007-05-23（万方平台首次上网日期，不代表论文的发表时间）