In Vitro Study of Thermal Changes in Optical Properties of Myocardium Tissue with Diffuse Reflectance Imaging
Optical properties of porcine myocardium tissue in the exposure temperature range of 37-80℃ were determined for 700, 750, 800, 850, 900 nm wavelengths of a Ti: sapphire laser. A neural network were trained with diffuse reflectance data from Monte Carlo simulations based on the semi-infinite tissue model, and then it was used to assess the absorption coefficient and reduced scattering coefficient from the spatially resolved relative reflectance which derived from diffuse reflectance image. The result showed that there was slight change in the absorption coefficient; the average for fresh is 0.11 mm-1, which increased to 0.17mm-1 for 80℃. The average reduced scattering coefficient of the five wavelengths for fresh samples is 0.14 mm-1, which increased obviously to 0.66 mm-1 for 80℃, and the average for all samples is 0.13 mm-1. The reduced scattering coefficient at the longer wavelength increased slowly compared with the shorter wavelength in the wavelength range of 700-900 nm. The average optical penetration depth of the five wavelengths for fresh samples is 3.37 mm, which reduced obviously to 1.54 mm for 80℃. In conclusion, thermal effect during photothermal treatment of tissue is an important factor altering optical properties of tissue.
Huilan Ao Da Xing Huajiang Wei Huaimin Gu
MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, South China Normal University, Guangzhou 510631, China
国际会议
北京
英文
1048-1053
2007-05-23（万方平台首次上网日期，不代表论文的发表时间）