The Study of Low-frequency Ultrasound to Enhance Transdermal Drug Delivery

摘要：

Low-frequency ultrasound(20 kHz ≤ f ≤100 kHz) has been extensively researched only in last 10 years. It has been shown to enhance transdermal transport of a variety of drugs. Transdermal drug delivery (TDD) offers several advantages over traditional delivery methods including injection and oral delivery. Low-frequency ultrasound has been shown to increase skin permeability to a variety of low-molecular as well as high-molecular weight drugs. The enhancement is determined by various parameters, including intensity, duty cycle, and application time. This review summarizes applications and mechanisms of low-frequency sonophoresis. Low-frequency ultrasound has been shown to synergistically enhance skin permeability with chemical enhancers iontophoresis and electroporation. Sonophoresis may therefore potentially be applied for non-invasive and painless delivery of drugs in the treatment of some disease.

作者: Jianguo Cui Yunlong Wei Hong Wang

作者单位: Chongqing Institute of Technology, Chongqing City 400050, P.R.China;Chongqing University, Chongqing Chongqing Institute of Technology, Chongqing City 400050, P.R.China

会议类型: 国际会议

会议名称: 2007 IEEE/ICME International Conference on Complex Medical Engineering-CME2007(CME2007 第二届国际复合医学工程学术大会)

会议地点: 北京

会议语种:英文

页码: 1228-1231

在线出版日期: 2007-05-23（万方平台首次上网日期，不代表论文的发表时间）