Evidence for Visual Analogue of Auditory Mismatch Negativity
Background: Mismatch negativity (MMN) of event-related potentials (ERPs) is useful in understanding the brain function, especially auditory perception and immediate memory. Auditory MMN (a-MMN) is characterized by several features. Visual analogue of MNN (v-MMN) has been reported, however, it is unknown about its properties. Objective: The aim of this study was to delineate functional characterization of v-MMN. Methods: Twelve normal adults were instructed to listen to a story and to also pay attention to a visual target. Windmill patterns consisting of a standard (S), a deviant (D), and a target (T) stimulus whose ratio was 8:1:1 were presented randomly. The difference of stimuli was the number of vanes. To ensure endogeneity, S and D stimuli were alternated. To vary deviancy, deviants were changed by modulating the number of vanes. To examine the effect of T stimulus on changes in detection, two target conditions were used. To elucidate sensory memory, additional experiments were performed in eleven subjects. Train bursts that consisted of one D and eight S stimuli were presented repeatedly with changing either inter-trains interval or sequence. Deviant-related component (DRC) was obtained by subtracting ERPs to the S from that to the D stimulus. Results: Subjects attention was directed to auditory context and the T stimulus. DRC appeared 150-300 ms after the stimulus onset and consisted of an early (DRN1) and a late (DRN2) component. Deviancy significantly influenced the latency of DRN2, while the change of the T stimulus affected latencies of both DRN1 and DRN2. More than four standards were necessary to obtain the negativity. Conclusions: Genuine visual analogue of a-MMN was demonstrated. Pre-attentive visual information processing can be estimated by using v-MMN.
Toshihiko Maekawa Shigenobu Kanba Shozo Tobimatsu
Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japa Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japa Department of Clinical Neurophysiology, Neurological Institute, Graduate School of Medical Sciences,
国际会议
北京
英文
1528-1531
2007-05-23（万方平台首次上网日期，不代表论文的发表时间）