Uncentered (centered) Correlation Clustering Method Fit for Establishing Theoretical p38 MAPK Signaling Pathway in Human Soft Tissue Sarcoma Samples
The aim of this research is to use and compare clustering technologies and find the best method for establishing theoretical p38 MAPK signaling pathway in human soft tissue sarcoma samples. We use and compare Uncentered (centered) correlation,absolute correlation (uncentere and centere), spearman rank correlation,kendalls tau, Edclidean distance, Edclidean distance harmonic and city-block distance similarity metric in centroid linkage, Single linkage, complete linkage, average linkage hierarchical clustering to arrange genes for setup signaling pathways according to similarity in pattern of gene. Our results show that only Uncentered (centered) correlation is consistent with the core unit of the cascade composed of from a MLK3(MAP3K11), a MKK6(map2k6), a p38 MAPK (mapk14), a MSK1(RPS6KA5) to a CREB. This study implies that Uncentered (centered) correlation clustering fit for establishing theoretical p38 MAPK signaling pathway in human soft tissue sarcoma samples which is consistent with biological experimental p38 MAPK signaling pathway.
p38 MAPK signaling pathway human soft tissue sarcoma samples.
Jinling Zhang Yinghua Lu Lin Wang -Stefan Wolfl Hongxin Zhang Bo Zhang Yunan Han Zhanqi Zhen
Biomedical center, The school of electronic engineering, Beijing University of Posts and Telecommuni The school of telecommunication and network technology, Beijing University of Posts and Telecommunic Biomedical center, The school of electronic engineering, Beijing University of Posts and Telecommuni Institute of Pharmacia & Molecular Biotech., Dept. Biology - Bioanalytic, University Heidelberg, 691
国际会议
北京
英文
1609-1613
2007-05-23（万方平台首次上网日期，不代表论文的发表时间）