The Kinetics Sudies of Peroxynitrite Decomposition Catalyzed by 5,10,15,20 - Tetrakis4-(3-Piridiniumproxy) Phenyl-PorphyrinCobalt(Ⅱ)

摘要：

peroxynitrite is a toxic biological oxidant which has been implicated in many pathophysiological conditions. Metalloporphyrins can catalyze it decomposition to protect the cells. A cobalt water Csoluble porphyrin Co( ) Ⅱ TPPOC3Py was synthesized and its ability to catalyze peroxynitrite decomposition was studied by stopped-flow spectrophotometer. The catalytic activity of Co(Ⅱ)TPPOC3Py is comparable to iron and manganese porphyrins which have been investigated before. The catalytic mechanism is related to the intermediate formed from the reaction of Co(Ⅱ)TPPOC3Py and peroxynitrite, and the catalytic ability depends on whether the intermediate is reduced easily.

作者: Wei Zhang Yunjing Luo Wenge Qiu Zhicheng Sun Rugang Zhong

作者单位: College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100022, China College of Environmental and Energy Engineering, Beijing University of Technology, Beijing 100022, C

会议类型: 国际会议

会议名称: 2007 IEEE/ICME International Conference on Complex Medical Engineering-CME2007(CME2007 第二届国际复合医学工程学术大会)

会议地点: 北京

会议语种:英文

页码: 1626-1629

在线出版日期: 2007-05-23（万方平台首次上网日期，不代表论文的发表时间）