Separation of 2-HPA by Capillary Electrophoresis

摘要：

The enantiomers of three chiral compounds of neural interest, N-(2-heptyl)propargylamine (2-HPA), 2-heptylamine (2-HA) and 2-HPPA were separated analytically using capillary electrophoresis (CE) with cyclodextrin chiral selectors. And dansyl chloride was chosen as the reagent for pre-column derivation to give 2-HPA derivatives. The effects of pH, β-CD concentration, electrolyte concentration and temperature et al. on the chiral separation are investigated in detail. CE is shown to be a simple, efficient, and inexpensive way to separate these three chiral compounds in laboratory.

关键词： dansylchloride chiral separation capillary electrophoresis 2-HPA

作者: Rongji Dai Lin Yang Wei Liu Yulin Deng

作者单位: School of Life Science and Technology, Beijing Institute of Technology, Beijing, 100081 China

会议类型: 国际会议

会议名称: 2007 IEEE/ICME International Conference on Complex Medical Engineering-CME2007(CME2007 第二届国际复合医学工程学术大会)

会议地点: 北京

会议语种:英文

页码: 1910-1913

在线出版日期: 2007-05-23（万方平台首次上网日期，不代表论文的发表时间）