Effect of Inhibition of Water-Soluble Propolis Extracts (WSPE) on Biomolecules Damage Induced by Peroxynitrte
Peroxynitrite (ONOO-) is a cytotoxicant with strong oxidizing and nitrating properties toward various biomolecules, including amino acids, DNA, lipids and proteins, thus can cause cell death, carcinogenesis or aging. The aim of this study was to investigate whether water-soluble propolis extracts (WSPE) could scavenge peroxynitre and further inhibit peroxynitrite-mediated tyrosine nitration,DNA strand breaks and low density lipoprotein (LDL) oxidation. The results show that WSPE have a strong ability to scavenge ONOO-, and its inhibition on ONOO- exhibited a concentration-dependent manner. It is suggested that propolis extracts might be developed as an effective peroxynitrite inhibitor for the prevention of ONOO- involved diaseses.
Yunjing Luo Liya Liu Ping Gong Rugang Zhong
College of Life Science & Bioengineering, Beijing University of Technology, Beijing 100022, China College of Art & Science of Beijing Union University, Beijing 100083, China
国际会议
北京
英文
2010-2013
2007-05-23(万方平台首次上网日期,不代表论文的发表时间)