Effect of Inhibition of Water-Soluble Propolis Extracts (WSPE) on Biomolecules Damage Induced by Peroxynitrte

摘要：

Peroxynitrite (ONOO-) is a cytotoxicant with strong oxidizing and nitrating properties toward various biomolecules, including amino acids, DNA, lipids and proteins, thus can cause cell death, carcinogenesis or aging. The aim of this study was to investigate whether water-soluble propolis extracts (WSPE) could scavenge peroxynitre and further inhibit peroxynitrite-mediated tyrosine nitration，DNA strand breaks and low density lipoprotein (LDL) oxidation. The results show that WSPE have a strong ability to scavenge ONOO-, and its inhibition on ONOO- exhibited a concentration-dependent manner. It is suggested that propolis extracts might be developed as an effective peroxynitrite inhibitor for the prevention of ONOO- involved diaseses.

作者: Yunjing Luo Liya Liu Ping Gong Rugang Zhong

作者单位: College of Life Science & Bioengineering, Beijing University of Technology, Beijing 100022, China College of Art & Science of Beijing Union University, Beijing 100083, China

会议类型: 国际会议

会议名称: 2007 IEEE/ICME International Conference on Complex Medical Engineering-CME2007(CME2007 第二届国际复合医学工程学术大会)

会议地点: 北京

会议语种:英文

页码: 2010-2013

在线出版日期: 2007-05-23（万方平台首次上网日期，不代表论文的发表时间）