A New Non-viral Conjugate as a Promising Carrier System for DNA Delivery

摘要：

A new non-viral conjugate, chitosan-g-PEI-g-PEG-OH polymer, was synthesized using grafting reaction with chitosan, polyethylenimine and polyethylene glycol for constructing amphiphilic grafting copolymers. The conjugates were characterized by IR and 1HNMR, and can self-assembled to form micelle-like nanoparticles in the aqueous media at the PH value of 5. The size of the nanoparticles was in the range of 30-50 nm. The hydrotropic polymer micelles provide an alternative approach for DNA delivery.

关键词： Polyethylene glycol Polyethylenimine Chitosan Non-viral carrier

作者: Yundong Wu Chengbin Liu Xiangyun Zhao Jiannan Xiang Shuming Nie

作者单位: College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China;Biomedical E College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China;Biomedical E

会议类型: 国际会议

会议名称: 2007 IEEE/ICME International Conference on Complex Medical Engineering-CME2007(CME2007 第二届国际复合医学工程学术大会)

会议地点: 北京

会议语种:英文

页码: 2014-2017

在线出版日期: 2007-05-23（万方平台首次上网日期，不代表论文的发表时间）