会议专题

Targeted Anticancer Drug Delivery System: Design and Synthesis

When anticancer drug, paclitaxel, is clinically used, solubility and toxicity are two major problems. To overcome these problems, in the present study, we design a targeted anticancer drug delivery system, which contains drug, drug carrier, and target-differentiated ligand. The key point is that both of paclitaxel and target-differentiated ligand, folate, chemically bond to a biocompatible carrier, heparin, via ester bond and amide bond, respectively. Model reaction indicates that 54% carboxyl groups on the drug carrier are substituted by the model drug and the total yield of model conjugates is ranged from 61 to 66%. The results promise to open a new door for the development of targeted drugs.

Ying Wang Jiawen Hu Jiannan Xiang

Biomedical Engineering Center, Hunan University, Changsha, 410082, China;College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China

国际会议

2007 IEEE/ICME International Conference on Complex Medical Engineering-CME2007(CME2007 第二届国际复合医学工程学术大会)

北京

英文

2018-2021

2007-05-23(万方平台首次上网日期,不代表论文的发表时间)