Targeted Anticancer Drug Delivery System: Design and Synthesis

摘要：

When anticancer drug, paclitaxel, is clinically used, solubility and toxicity are two major problems. To overcome these problems, in the present study, we design a targeted anticancer drug delivery system, which contains drug, drug carrier, and target-differentiated ligand. The key point is that both of paclitaxel and target-differentiated ligand, folate, chemically bond to a biocompatible carrier, heparin, via ester bond and amide bond, respectively. Model reaction indicates that 54％ carboxyl groups on the drug carrier are substituted by the model drug and the total yield of model conjugates is ranged from 61 to 66％. The results promise to open a new door for the development of targeted drugs.

作者: Ying Wang Jiawen Hu Jiannan Xiang

作者单位: Biomedical Engineering Center, Hunan University, Changsha, 410082, China;College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China

会议类型: 国际会议

会议名称: 2007 IEEE/ICME International Conference on Complex Medical Engineering-CME2007(CME2007 第二届国际复合医学工程学术大会)

会议地点: 北京

会议语种:英文

页码: 2018-2021

在线出版日期: 2007-05-23（万方平台首次上网日期，不代表论文的发表时间）