Antiepileptic Effects of Repetitive Transcranial Magnetic Stimulation

摘要：

We studied the antiepileptic effects of repeptitive transcranial magnetic stimulation (rTMS) in two epilepsy model rodents. In the genetically epileptic EL mice, low-frequency rTMS (1Hz, 100％ of motor threshold (MT), 300 pulses/day, once a week) inhibitied the development of epileptogenesis transiently. On the other hand, in the pentylenetetrazol (PTZ)-induced convulsive Wistar rats, rTMS (0.5 Hz, 200 ％ of MT, 1000 pulses, applied 30 minutes before PTZ injection) significantly extended the latency to the onset of seizures and decrease the number of the development of status epilepticus. Our results suggest that low-frequency rTMS has the antiepileptic effects, but the efficacy is varied according to the epilepsy model animals we used.

作者: Tomoaki Yuhi Naoki Akamatsu Yukiko Fueta Takenori Uozumi Sadatoshi Tsuji

作者单位: Department of Neurology, University of Occupational and Environmental Health, School of Medicine, Ki First Department of Environmental Management, University of Occupational and Environmental Health, S

会议类型: 国际会议

会议名称: 2007 IEEE/ICME International Conference on Complex Medical Engineering-CME2007(CME2007 第二届国际复合医学工程学术大会)

会议地点: 北京

会议语种:英文

页码: 2048-2051

在线出版日期: 2007-05-23（万方平台首次上网日期，不代表论文的发表时间）