Bioinformatics Analysis of PSD-95 Structure and Its Interacting Partners
Postsynaptic density-95 (PSD-95/SAP-90), a major protein component of postsynaptic density (PSD), is an abundant postsynaptic scaffolding protein that plays an important role in synapse maturation and synaptic plasticity. It has three PDZ domains, one SH3 domain, and one guanylate kinase (GK) domain. Through these domains, PSD-95 performs important roles in recruiting other dendritic and transmembrane proteins, such as NMDA receptors, SPAR, and NE-dlg/SAP102, and mediating the interactions of these proteins, In this article, we try to use bioinformatics tools to analyze the structure of these domains and search the interacting partners of PSD-95. This will provide insight into the functions of PSD-95.
Chenyi Pan Xiao Wang Wenqi Zhu Jian Wang Zhaohui Zhang Ming Chen
College of Life Sciences, Zhejiang University, Hangzhou 310058, China College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310
国际会议
杭州
英文
886-897
2007-04-01（万方平台首次上网日期，不代表论文的发表时间）