Multipotent antioxidants: from screening to design
Free-radicals play an important role in the pathogenesis of many diseases, accounting for continuing interest in the identification and development of novel antioxidants that prevent radical-induced damage. To develop more-powerful weapons that address complex diseases in which free-radicals might be significant, but not exclusive drivers, antioxidants that also have other pharmacological effects are desired. To obtain multipotent antioxidants, one can screen drug collections and/or natural-product libraries, or couple an antioxidant group with other pharmacophores. It is interesting to note that most rationally designed multifunctional antioxidants are structurally different from their naturally occurring counterparts. Therefore, natures design strategy provides important clues as to how the design concept for multipotent antioxidants can be improved.
Hong-Yu Zhang Da-Peng Yang Guang-Yan Tang
Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Center for Advanced Study, Shandong University of Technology,Zibo 255049, R.R. China
国际会议
杭州
英文
1159-1164
2007-04-01（万方平台首次上网日期，不代表论文的发表时间）