Naturally occurring multipotent anti-Alzheimers agents
Alzheimers disease (AD) is one of the greatest challenges to modern medicine because multiple pathogenetic factors are implicated in the disease and some are still unclear. Because the hitting-one-target therapeutic strategy has proved to be inefficient to AD, finding multipotent agents that can aim at multiple targets is attracting increasing attention. Although multifunctional agents can be produced by incorporating at least two pharmacophores in one framework, naturally occurring counterparts are more attractive. The authors describe the profile of naturally originated multipotent anti-AD compounds and the structural features of these compounds are summarised. Building on the structure-activity relationships, the authors identify more pleiotropic agents from natural product libraries, all of which are of great interest for further development.
acetylcholinesterase inhibitor Alzheimers disease amyloid aggregation inhibitor,antioxidant metal ion chelator monoamine oxidase inhibitor
Hong-Yu Zhang Da-Peng Yang Hong-Fang Ji
Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Center for Advanced Study, Shandong University of Technology, Zibo 255049, PR China
国际会议
杭州
英文
1167-1175
2007-04-01（万方平台首次上网日期，不代表论文的发表时间）