Multiscale simulation for nanomechanical behavior of gene chips in label-free biodetection
The modeling methods and computing skills in statistical mechanics, polymer chemistry and continuum mechanics are combined to establish a mu Id scale model for nanomechanical behavior of gene chips in label-free biodetection in order to obtain the relationship between nanomechanical deflection of gene chips and some factors such as nanoscopic structural features of DNA molecules, salt concentrations in buffer solutions, and macroscopic physical parameters of gene chips etc. Numerical results show that the sign of the piezoelectric constant of DNA layer may result in the upward or downward bending of chips during single-strand DNA (ssDNA) molecules immobilization on chip surface.
Neng-hui Zhang Jing-jing Xing Jin-ying Shan
Shanghai Institute of Applied Mathematics and Mechanics, Shanghai University, Shanghai 200072, China Shanghai Institute of Applied Mathematics and Mechanics, Shanghai University, Shanghai 200072, China
国际会议
The 5th International Conference on Nonlinear Mechanics(第五届国际非线性力学会议)
上海
英文
562-565
2007-06-11（万方平台首次上网日期，不代表论文的发表时间）