Electrodynamics of ion channel of biological cell
A theoretical model for studying ion transport across cell membranes in electromagnetic fields is introduced in this article. Some analyses are given for the study of electrodynamic responses of ion channels. It is shown that classical Nemst-Plarjcks results and the Goldman-Hodgkm-Katz current and voltage equations can all be recovered by the model for ion channels in time-independent steady state. For ion channels in time-varying fields, it is further shown that both the ionic current and displacement current contribute to the total current in the ion channel, which depend not only on the equilibrium susceptibility of the mixture, but also on the dissipative polarization relaxation, the concentration and distribution of the ions in the mixture as well as on the effect of coupling between the polarization relaxation and diffusive fluxes of ions of different species. At the linear approximation and with the Goldman constant field assumption, the dissipative admittance of the ion channel can be derived analytically in one-dimensional case for characterizing frequency response of the ion channel in time-harmonic fields.
Shu-ang Zhou
Department of Biomedical Engineering, Washington University in St. Louis, MO 63130-4899, USA
国际会议
The 5th International Conference on Nonlinear Mechanics(第五届国际非线性力学会议)
上海
英文
760-767
2007-06-11（万方平台首次上网日期，不代表论文的发表时间）