ANALYSIS OF IL-1B-511 and IL-1B-31 POLYMORPHISMS ON SUSCEPTIBILITY TO TUBERCULOSIS
The aim of this study was to test whether the IL - 1β gene promoter region polymorphisms could be useful genetic markers for susceptibility to patients with tuberculosis (TB). A normal control group of 105 healthy people and another group of 98 patients with TB (40 pulmonary TB, 28 pulmonary TB with extrapulmonary TB and 30 extrapulmonary TB) were examined. PCR-restriction fragment length polymorphism(PCR-RFLP) analysis was done for the IL- 1β gene polymorphisms (-31 and -511) using endonucleases AluI and AvaI, respectively. The frequencies of IL- 1β-511 gene were not statistically different between controls and all patients with TB(P＞0.05). There were an increases in both-31 T alleles and TT genotypes frequencies in all patients with TB compared to controls (54.1 vs 42.4％, OR= 1.60, P=0.018 and 33. 7 vs 10. 5％, OR=4.34, P=0.0001, respectively), and a specific decrease in - 31 CT genotype frequency (40. 8 vs 63. 8％, OR=0.39, P=0.001). The pulmonary TB or extrapulmonary TB carrying -31 TT genotype showed a significant increased risk (OR=3.66, P=0.004 and OR=7.48, P=0.00001, respectively) compared with controls, but- 31 CT genotype was associated with a decreased risk of pulmonary TB and extrapulmonary TB (OR=0.34, P=0.004 and OR=0.38. P=0.02, respectively). The results indicate that IL -1β-31 TT genotype had a significant increased risk and IL - 1β- 31CT genotype had a significant decreased risk in pulmonary TB or extrapulmonary TB compared with controls.
Interleukin-1beta polymorphisms tuberculosis
Jiejing Zhang Fengyan Pei Hong Shen Haiying Wang Yunshan Wang Jun Liu
Department of Biochemistry, School of Medicine, Shandong University,Jinan 250012, China Central Laboratory, Jinan Central Hospital, Clinical Medical College, Shandong University,Jinan 2500 HanGuang Center,Shandong Chest Hospital, Jinan 250013, China Department of Medical Genetics and Microbiology, University of Toronto,Toronto, Ontario M5S 1A8, Can
国际会议
The 4th International Forum on Post-genome Technologies(4IFPT)(第四届国际后基因组生命科学技术学术论坛)
杭州
英文
73-76
2006-09-25（万方平台首次上网日期，不代表论文的发表时间）