COMPELLING ASSOCIATION OF ASPARTIC ACID REPEAT POLYMORPHISM IN THE ASPORIN GENE WITH KNEE OSTEOARTHRITIS SUSCEPTIBILITY IN HAN CHINESE POPULATION

摘要：

A debating genetic association with osteoarthritis (OA) of functional alleles in the aspartic acid (D) repeat of the asporin gene was recently reported in Japanese, the United Kingdom, Greek and Spanish Caucasians. Our objective was to assess whether the D repeat polymorphism is associated with knee OA in Han Chinese population. The D repeat was genotyped in 218 patients who suffered from primary knee OA and in 454 age-matched controls who never had any clinical symptoms of OA, and association was examined. D14 allele was significantly over represented in KOA patients (P=0. 001 3, OR=2. 04, 95％CI=1. 32-3.15). The data of D14 versus D13 suggested that it was similar to data of D14 versus others CP=0. 005 2, OR=1.88, 95％CI=1. 21 - 2. 92). There were no significant differences in other comparisons. Our data show compelling association aspartic acid repeat polymorphism residues in the asporin gene with knee OA susceptibility in Han Chinese population. Our results, together with reports from Japan, indicate that D14 allele of asporin is an important factor in knee OA susceptibility at least among East Asians.

关键词： Microsatellite polymorphism knee osteoarthritis Han Chinese population

作者: Dongquan Shi Qing Jiang Long Yi, PhD Yong Wang, PhD Jin Dai MM

作者单位: The Center of Diagnosis and Treatment for Joint Disease. Drum Tower Hospital,affiliated to Medical S Department of Pathology, Medical School of Nanjing University, Nanjing 210008, China

会议类型: 国际会议

会议名称: The 4th International Forum on Post-genome Technologies(4IFPT)(第四届国际后基因组生命科学技术学术论坛)

会议地点: 杭州

会议语种:英文

页码: 95-98

在线出版日期: 2006-09-25（万方平台首次上网日期，不代表论文的发表时间）