(tttta)n POLYMORPHISM IN THE PROMOTER OF GENE OF P450scc IN THE PATHOGENSIS OF POLYCYSTIC OVARY SYNDROME IN CHINESE WOMEN

摘要：

To investigate the functional significance of microsatellite polymorphism (tttta) n in the promoter of gene of P450scc (CYP11a) in the pathogensis of polycystic ovary syndrome. Two hundred and one patients and 147 controls were studied. Menarche age was investigated. Body mass indices were determined. Blood samples were obtained for DNA analysis and hormone measurements. The genotype distribution of CYP11a is statistical difference between patients with PCOS and controls (Fishers Exact Test (2-Tail), p=0. 031). 4//8 and 6//6 genotype individuals were statistically different among patients and controls (1. 5％ and 6.1％, respectively,X2= 5.467,p = 0.019; 57. 7％ and 32. 8％, respectively, X2= 5. 588,p=0. 018). BMI of the 4//4 genotype patients is statistically lower than that of 4//6, 6//6, and 6//8 genotype patients (p=0. 003 7, 0. 002 7, 0. 059, respectively). No differences were observed in serum hormone concentrations among different genotype individuals in patients with PCOS. The allele (tttta)n distribution in the promoter of CYP11a is greatly different between Chinese Han woman and Spain, Greek, UK, or other Europid women and is statistical different between patients with PCOS and controls. Despite we did not find the difference with hyperandrogenism among the different genotypes of patients with PCOS, we hold that the (tttta) n pentanucleotide polymorphism plays a certain extent role in the pathogenesis of PCOS.

关键词： Polycystic ovary syndrome hyperandrogenism enzyme P450scc gene CYP11a microsatellite polymorphism

作者: Yong Wang, Ph. D. Ying Zou, M. Sc Xiaoke Wu, M. D. , Ph. D. Long Yi, Ph. D. Junwei Qu, Ph. D.

作者单位: Center for Public Health Research, Medical School of Nanjing University, Nanjing 210093, China Center for Public Health Research, Medical School of Nanjing University, Nanjing 210093, China;The F

会议类型: 国际会议

会议名称: The 4th International Forum on Post-genome Technologies(4IFPT)(第四届国际后基因组生命科学技术学术论坛)

会议地点: 杭州

会议语种:英文

页码: 178-182

在线出版日期: 2006-09-25（万方平台首次上网日期，不代表论文的发表时间）