ELECTROCHEMICAL CONTACT ANGLE STUDY ON BIORECOGNITION OF DOXORUBICIN WITH DNA BASED ON THE CdS NANOPARTICLES
In present report, the effect of Cd2+-enriched CdS nanoparticles on the electrochemical behavior and hydrophobic/ hydrophilic properties of doxorubicin-DNA target system has been explored by using in situ electrochemical contact angle measurements. It was observed that Cd2+ -enriched CdS nanoparticles could remarkably affect the contact angle variation between oxidation and reduction forms of doxorubicin upon application of the corresponding potentials. Moreover, the site-selective DNA binding of doxorubicin in the presence of CdS nanoparticles has been demonstrated by both electrochemical contact angle measurements and atomic force microscopy (AFM) studies, indicating that CdS nanoparticles could facilitate the interaction of doxorubicin with DNA and accordingly influence the hydrophobic/hydrophilic properties of the target system during the biological recognition process. These observations suggest that the nano-interface of CdS may offer great promising application in biomolecular recognition or switchable devices in bioelectronic systems.
CdS nanoparticles doxorubicin DNA recognition hydrophobic/hydrophilic properties in situ electrochemical contact angle measurement
Chunhui Wu Chen Chen Xuemei Wang
State Key Lab of Bioelectronics (Chien-Shiung WU Lab), Southeast University, Nanjing 210096, China
国际会议
The 4th International Forum on Post-genome Technologies(4IFPT)(第四届国际后基因组生命科学技术学术论坛)
杭州
英文
237-240
2006-09-25（万方平台首次上网日期，不代表论文的发表时间）