SELF-ASSEMBLED POLYGLYCEROL DENDRIMER FOR BOTTOM-UP TYPED NANO-FABRICATION
A polyglycerol dendrimer of generation 4 (PGD- G4) has been studied as a hydrotropic dendrimer1,2. Here, PGD-G4 was conjugated with some hydrophobic moieties, and self-assembled structure of the conjugate in water was analyzed by 1 H - NMR, dynamic light scattering (DLS) and atomic force microscopy (AFM). One cholesterol or stearic acid (C18) molecule was conjugated to PGD-G4, which was confirmed by MALDI - TOF mass spectroscopy. The DLS analysis showed that the conjugate formed self-assembly. The AFM image suggests that the selfassembly is a micelle-like sphere. When stearic acid was conjugated with PGD- G4, self-assembled structure of stearyl PGD-G4 is dependent on the concentration. The concentration-dependent association of the stearyl group led to formation of micelles, with either particle-like or rod-like structure. Therefore, the PGD-based self-assemblies are good candidate of nano-biomaterials to achieve bottom-up typed nano- fabrication.
Polyglycerol dendrimer self-assembly nano-fabrication
Tooru Ooya Hidetaka Akita
Department of Intelligent Systems Design Engineering, Toyama Prefectural University,Toyama 939-0398, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6,Sapporo 060-0812,
国际会议
The 4th International Forum on Post-genome Technologies(4IFPT)(第四届国际后基因组生命科学技术学术论坛)
杭州
英文
274-276
2006-09-25（万方平台首次上网日期，不代表论文的发表时间）