ASSOCIATION ANALYSIS BETWEEN RELN GENE AND AUTISM BASED ON MICROARRAY METHOD
Autism is a pervasive developmental disorder (PDD) characterized by deficits in language development, social interaction and stereotypical, repetitive behaviors. Family and twin studies have provided compelling evidence for a strong genetic component in most idiopathic cases. Several genome-wide screens indicated that chromosome 7q was linked to Autism. RELN gene, located in 7q22, encodes a large secreted extracellular matrix protein thought to control cell-cell interactions critical for cell positioning and neuronal migration during brain development. We genotyped three single nucleotide polymorphisms (SNPs) of RELN gene in 82 Chinese Han trios using microarray method, and performed a family-based association study using the analysis of transmission disequilibrium test (TDT). In conclusion, our studies suggest that it is unlikely that these three SNPs in RELN gene play a significant role in the genetic predisposition to autism.
Autism RELN microarray association
Yao Yang Wanqiong Qiao Lu Cheng Pengfeng Xiao Zuhong Lu
State Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096, China State Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096, China;Research Center
国际会议
The 4th International Forum on Post-genome Technologies(4IFPT)(第四届国际后基因组生命科学技术学术论坛)
杭州
英文
303-305
2006-09-25（万方平台首次上网日期，不代表论文的发表时间）