FLUORESCENT CHEMOSENSORS FOR ANALYZING PHOSPHATE DERIVATIVES
The development of molecular recognition and sensing systems for biologically important anions received considerable attention in recent years. Among various anions, phosphate species, including nucleotide pyrophosphates such as ATP, inorganic pyrophosphate, phosphoproteins, have been regarded as significant sensing targets because of their pivotal roles in biological systems. A new fluorescent chemosensor for phosphate derivatives was developed. The xanthone-type chemosensor bearing two Dpa-Zn ( Ⅱ) sites displays a triple-signaling excitation spectrum change upon binding to the phosphates that enables ratiometric fluorescent analysis. The unique excitation signaling is based on the phosphate-binding induced coordination chemistry change at the xanthone fluorophore, which alters the photophysical property of the chemosensor.
Chemosonsor fluorescence phosphate anion sensing
Itaru Hamachi
Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering,Kyoto University, Katsura Kyoto 615-8510, Japan
国际会议
The 4th International Forum on Post-genome Technologies(4IFPT)(第四届国际后基因组生命科学技术学术论坛)
杭州
英文
322-324
2006-09-25（万方平台首次上网日期，不代表论文的发表时间）