GENOME-WIDE ANALYSIS OF DNA BINDING SITES OF PROTEIN JUN
Transcription factor binding site(TFBS) is a kind of short DNA sequence which length is about 6-20 nt long and locates mainly on the regulation region of the target genes. To identify the TFBSs of one transcription factor(TF) is a key procedure for revealing the gene regulatory network. Jun is a protein and is one component of AP - 1 that plays an important role in regulating apoptosis and cell death of cell. Genome-wide analysis of Juns TFBSs is performed Instead of matrix search, some certain sequences of Jun with high matrix similarity score are used to scan through the human genome and the proximal promoter region of all human genes. The distribution of these TFBSs at different regions of genome is further analyzed. Compared with the TFBSs contribution of the known target genes of AP - 1 and GO-derived genes, some clues are obtained to improve the prediction accuracy of the target genes based on the TFBS matrix of one TF. The method and the results will promote the study of the deducing of gene regulatory network.
Transcription factor binding site(TFBS) human genome genome-wide pattern matching gene ontology(GO) bioinformatics
Jianming Xie Minli Li Xiao Sun Zuhong Lu
State key laboratory of Btoelectronics, Southeast university, Nanjing 210096, China
国际会议
The 4th International Forum on Post-genome Technologies(4IFPT)(第四届国际后基因组生命科学技术学术论坛)
杭州
英文
365-369
2006-09-25（万方平台首次上网日期，不代表论文的发表时间）