CLINICAL VALUES OF COMBINED HEPATOMA-SPECIFIC AFP FRACTION AND AFP-mRNA DETERMINATION IN DIAGNOSIS AND DIFFERENTIATION OF HEPATOCELLULAR CARCINOMA
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide. HOC prognosis is poor and early detection is of the utmost importance. Although serum alpha-fetoprotein (AFP) is a useful tumor marker for the detection and monitoring of HCC development, the false-negative or false-positive rate with AFP level alone may be as high as 30 ％ - 40 ％ for patients with small size HCC. To enhance the specificity and accuracy of AFP for HCC diagnosis, we analyzed AFP expression statues in liver tissues, detected serum hepatoma-specific ALP fraction CALP-L3) and AFP-mRNA from peripheral blood mononuclear cells (PBMCs), and explored their clinical implications for HCC diagnosis.
HCC HS-AFP AFP-mRNA affinity chromatography immunohistochemistry RT-PCR
Wei Wu Dengfu Yao Liwei Qiu Xinhua Wu
Research Center of Clinical Molecular Biology, Affiliated Hospital of Nantong University,Nantong 226001, China
国际会议
The 4th International Forum on Post-genome Technologies(4IFPT)(第四届国际后基因组生命科学技术学术论坛)
杭州
英文
443-446
2006-09-25（万方平台首次上网日期，不代表论文的发表时间）