COMPARISON OF NK CELL IMMUNOPHENOTYPES AND Th1/Th2 IMMUNITY BETWEEN UTERINE BASAL DECIDUA AND PERIPHERAL BLOOD IN HUMAN TERM PREGNANCY
NK cells and Th1/Th2 immunity play an important part in the pregnancy immune. In order to investigate the immune state in maternal-fetal interface and peripheral blood in human normal term pregnancy, the number of NK cell subsets, NK cell receptors- CD69, CD94 and Th1/Th2 immunity in basal decidua and peripheral blood were determined in 10 cases of normal term pregnancies by flow cytometric analysis. We found that the percentage of CD56bright CD16-uNK cells in decidua was (18. 72 ±17. 73) ％, CD56+CD69+uNK cells was (34. 98±19. 79) ％, CD56bright CD94+uNK cells was (15. 94±3. 19) ％ and the ratio of CD56+CD16-/CD56+CD16+was (2. 30±2.25). CD56+CD69+/CD56+CD94+was (1. 21±0. 66). and the percentage of CD56bright CD16-NK cells in peripheral blood was (0. 28±0. 18) ％, CD56+ CD69+ NK cells was (3. 33±1. 27) ％, CD56bright CD94+NK cells was (1.17±1. 19) ％ and the ratio of CD56+CD16-/CD56+CD16+ was (0. 34±0. 28), CD56+CD69+/CD56+CD94+ was (0.28±0. 12), there were statistical differences between in basal decidua and peripheral blood (p＜0.01); While the number of Th1. Th2. Tc1 cells and the Th1/Th2, Tc1/Tc2 ratio had no statistical difference( p＞0. 05); the proportion of NK cell subsets, NK cell receptors: CD69, CD94 and Th1/Th2 immunity in basal decidua were not correlated with those in peripheral blood (p＞0. 05). So the presentation of activated NK cells and T cells are involved in the mechanism of immune tolerance of pregnancy, the immunity of NK cells and T cells in basal decidua is independent of that of systematic immunity.
Decidua uNK celt th1/th2 immunity human NK cell
Jianjun Zhou Sha Hao Yali Hu Yayi Hou Zhiqun Wang Yiming Dai Jingxian Ling
Department of Obstetrics and Gynecology, The Affiliated Drum Tower Hospital of Nanjing University Me Immunology and Reproductive Biology Lab, Medical School, Nanjing University, Nanjing 210093, China
国际会议
The 4th International Forum on Post-genome Technologies(4IFPT)(第四届国际后基因组生命科学技术学术论坛)
杭州
英文
452-455
2006-09-25（万方平台首次上网日期，不代表论文的发表时间）