ENVIRONMENT ENDOCRINE DISRUPTOR NONYLPHENOL MODULATED ABP AND INHIBIN GENE EXPRESSION IN CULTURED RAT TESTICULAR SERTOLI CELL
Nonylphenol (NP) is a contaminant widely distributed in the environment. As an important environment endocrine disruptor, Nonylphenol has been documented to disturb male reproduction in a large number of literatures. In the present study, it was verified that Nonylphenol could influence gene expression of rat testicular Sertoli cells. Nonyfphenol at concentrations used in the study (0. 1, 10 and 20 μM) didnt cause visible cell morphological changes, but significantly modulated ABP and inhibin gene expression. Gene transcription of ABP was enhanced at low concentrations (0. 1 and 10 μM) of Nonylphenol, but was suppressed at higher concentration (20 μM). However, Nonylphenol showed a stimulative effect on inhibin gene expression at all the concentrations used. Taken together, Nonylphenol could cause a significant disturbance of ABP and inhibin gene transcription in Sertoli cell, which might provide a new sight onto the mechanism of Nonylphenols influence on male reproduction.
Sertoli cell androgen-binding protein( ABP) inhibin gene expression
Yi Gong Daqiang Ying Xiaodong Han
Immunology and reproductive biology Laboratory, Medical School, Nanjing University,Nanjing 210093, C State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment,Nanjing Univ
国际会议
The 4th International Forum on Post-genome Technologies(4IFPT)(第四届国际后基因组生命科学技术学术论坛)
杭州
英文
476-479
2006-09-25（万方平台首次上网日期，不代表论文的发表时间）