EXTERNAL CONTROL OF THE METABOLISM AND THE CELLULAR COMMUNICATION BY THE NEWLY DEVELOPED MICRO-GRID SYSTEM
Cellular slime mold, Dtctyostelium discoideum, is the unicellular amoeba. However, on starvation they communicate each other by cAMP pulses, and the differentiation from the single cell state to the multicellular state is controlled by the different type of cAMP pulses. To utilize such characters for the quantitative study we propose a new micro-grid system that enables the external control of the metabolism and the differentiation. Our micro-grid system can create various cAMP pulses and send them to the target amoebae. Thus, we control the cellular differentiation externally for the quantitative analysis. We also plan to use cell clusters trapped in the micro welts as artificial organs, too.
Shunsuke Sakurai Rho Kimura Seido Nagano Toru Hiranishi Setoshi Konishi
Department of Bioscience and Bioinformatics, Rttsumeikan University 1-1-1 Nojihigashi, Kusatsu,Shiga Department of Micro System Technology, Ritsumeikan University 1-1-1 Nojihigashi, Kusatsu,Shiga 525-8
国际会议
The 4th International Forum on Post-genome Technologies(4IFPT)(第四届国际后基因组生命科学技术学术论坛)
杭州
英文
495-497
2006-09-25（万方平台首次上网日期，不代表论文的发表时间）