Cellular and Molecular Mechanisms Regulating Airway Smooth Muscle Function
In this review, excitation-contraction coupling as well as synthetic function of airway smooth muscle (ASM), defined as the ability to secrete imrnunomodulatory cytokines and chemokines and to express cell surface receptors that are important in cell adhesion and leukocyte activation, will be reviewed. Pharmacologic approaches to modify die synthetic function of ASM and how altered synthetic function may contribute to airway remodeling will also be defined. ASM in asthma is the pivotal cell regulating bronchomotor tone. Recent evidence suggests that ASM may also modulate airway inflammation and perpetuate airway remodeling. A variety of signaling pathways regulate ASM cytokine-chemokine secretion as well as cell adhesion molecule expression. Interestingly, these signaling pathways appear to be disparate from those of trafficking leukocytes.
Airway remodeling asthma chronic obstructive pulmonary disease (COPD)
Reynold A. Panettieri
Pulmonary, Allergy and Critical Care Division, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
国际会议
上海
英文
26-36
2006-11-16（万方平台首次上网日期，不代表论文的发表时间）