Frequency Dependence of the Spatial Pattern of Synchronized Activity in Rat Hippocampus in Vivo And in Vitro
The Spatiotemporat activity evoked in the hippocampal CA1 by contralateral CA3 stimulation was investigated in vivo. Spatial activity was localized and the spatial size of the activity depended on stimulus frequency. LTP induced by tetanic stimulation of contralateral CA3 just emphasized spatiotemporal activity and did not influence the spatial size of the activity, in vitro, Spatiotemporal activity evoked by periodic stimulation of stratum moleculare in DG was recorded from the stratum pyramidale in CA3. Spatial activity was localized and depended on stimulus frequency as well as in vivo. Responses of the hippocampal CA1 and CA3 was highly dependent on the stimulus frequency in vivo and in vitro both, and 20-30 Hz stimulation seemed to be optimal to drive hippocampus. However, enhanced activity caused by such stimulation was stably localized and did not spread across the hippocampus resulting in epileptic activity. The size of the localized activity was consistent with the lamella hypothesis.
Koushi Nakashima Tomohiro Umemura Hatsuo Hayashi Satoru Ishizuka
Information Science Center,Kyushu Institute of Technology lizuka 820-8502, Japan Department of Brain Science and Engineering,Graduate School of Life Science and Systems Engineering,
国际会议
8th International Conference on Neural Information Processing(ICONIP 2001)(第八届国际神经信息处理大会)
上海
英文
47-51
2001-11-14（万方平台首次上网日期，不代表论文的发表时间）