Plasticity of Synapses between Retinal Cones and Horizontal Cells and Model Analysis
(0) In the carp retina, the luminosity type horizontal cell (LHC) receives input from both redand green-sensitive cone systems. The response characteristics, particularly the spectral sensitivity, of LHC are stimulus pattern dependent. Stimulating one cone system using repetitive light flashes of selected wavelength enhances the signal transmission efficacy between the stimulated cone system and the LHC, and inhibits the LHCs responsiveness to the signals from the unstimulated cone system. A mathematical model is developed in this study to investigate the possible physiological mechanism underlying such auto-enhancement and mutualdepression effects. The model consists of two parallel signal pathways, which are the red- and greensensitive cone signal pathways respectively. The strength of synapses between the relevant neurons of each signal pathway is represented by its gain term; a linear summation of the output of each pathway forms the system output, which represents the LHCs light response amplitude. It was assumed in the model that the status of each pathway is modifiable, i.e., the gain of each pathway is positively related to its response status and negatively related to the system output, which reflects the possibility of meta-plasticity in the local neuronal circuitry, With the parameters carefully determined, the model prediction describes the experimental observations reasonably well.
retina stimulus pattern synaptic plasticity model analysis
Yu Liu Jian-Feng Hu Lei Zheng Tian-Ge Zhuang Pei-Ji Liang
Shanghai Institute of Physiology, Shanghai Institute for Biological Sciences, Chinese Academy of Sci Department of BME, Shanghai Jiao-tong University, Shanghai 200030, China
国际会议
8th International Conference on Neural Information Processing(ICONIP 2001)(第八届国际神经信息处理大会)
上海
英文
1289-1292
2001-11-14（万方平台首次上网日期，不代表论文的发表时间）