Impacts of anti-dsDNA antibody on in vitro-fertilization-embryo transfer and frozen-thawed embryo transfer
Purpose: To explore whether anti-dsDNA antibody,which was demonstrated to enter living cells and induced apoptosis,could adversely affect reproductive outcomes.Methods: A total of 259 women receiving in vitro fertilization-embryo transfer cycle(IVF) were enrolled in this study,including 52 women with positive ANA and anti-dsDNA(ANA+/anti-dsDNA+ group),86 women with positive ANA and negative anti-dsDNA(ANA+/anti-dsDNA-group),121 women with negative ANA and anti-dsDNA(ANA-/anti-dsDNA-group).136 non-pregnant women among 259 patients in IVF-ET cycle were enrolled in hormone replacement therapy frozen-thawed embryo transfer cycle(HRT-TET).We compared number of retrieved oocytes,available embryos and high-quality embryos,rates of implantation,clinical pregnancy and abortion among three groups in fresh embryo transfer and frozen-thawed embryo transfer cycle respectively.Result(s):Number of retrieved oocytes,available embryos and high-quality embryos in ANA+/anti-dsDNA+ group were lowest than other two groups in fresh embryo transfer cycle.Rates of fertilization,implantation,clinical pregnancy in ANA+/anti-dsDNA+ group were lowest,while early miscarriage rate was highest in ANA+/anti-dsDNA+ group both in fresh embryo transfer cycle and frozen-thawed embryo transfer cycle.Conclusion(s): Our data suggested that anti-dsDNA antibody may be the essential marker for defective oocytes or embryos in infertile women with any type of ANA.
Anti-dsDNA antibody antinuclear antibody oocyte embryo
Jiao Fan Yiping Zhong Cuina Chen
Reproductive Medicine Center for The Central people”s hospital of Huizhou City, Huizhou, People”s Republic of China, 516001
国内会议
广东惠州
英文
339-349
2017-07-14（万方平台首次上网日期，不代表论文的发表时间）