Effect of vitamin D supplementation for patients with pulmonary tuberculosis: A Meta-Analysis
Purpose: The objective of this study was to assess the efficacy of vitamin D as an adjunctive therapy in patients with pulmonary tuberculosis.Methods: Medline, SCOPUS, Google Scholar, EMBASE, Springer, and Science Direct were searched electronically.Relevant journals and references of studies included were hand-searched for Randomized controlled trials (RCT) and Controlled clinical trials (CCT) regarding the efficacy of vitamin D supplementation in patients with pulmonary tuberculosis.Two reviewers independently performed data extraction and quality assessment.Data were analyzed using RevMan 5.3 software by The Cochrane Collaboration.Results: Five studies were included.To compare the sputum smear conversion rote of vitamin D supplementation and control group, the pooled RR (Risk Ratio) and its 95% CI was-2.29 (-8.87, 4.30), with no statistical significance (P=0.50).Consistently, the pooled mean difference and its 95% CI was 0.11 (-0.85, 1.07), with no statistical significance (P=0.82) when analyzing body mass index (BMI).Considering inflammation, the pooled mean difference and its 95% CI of ESR was-2.29 (-8.87,4.30), with no statistical significance (P=0.50).Moreover, the difference of serious adverse events between vitamin D supplementation and placebo was 0.79 (95% CI:0.42 to 1.49), with no statistical significance (P=0.47).Conclusion: vitamin D supplementation had some capability of improving sputum smear negative conversion rates and BMI, as well as reducing ESR and serious adverse events, but there was no significant difference between vitamin D supplementation group and control group.
vitamin D adjunctive therapy pulmonary tuberculosis efficacy meta-analysis
Ji Wang Malong Feng Shidong Ying Jianfang Zhou Xiaoqing Li
Department of Infectious Diseases, People”s hospital of Fenghua District, Ningbo,Zhejiang Province Ningbo, Zhejiang 315500
国内会议
杭州
英文
450-459
2017-10-01（万方平台首次上网日期，不代表论文的发表时间）