Hepatocellular Carcinoma with Portal Vein Tumor Thrombus:Treatment with Transarterial Chemoembolization Combined with Computed Tomography-guided 125Iodine Implantation--A Retrospective Cohort Study
Purpose We conducted a retrospective evaluated the safety and efficacy of transarterial chemoembolization (TACE) combined with computed tomography-guided 125iodine implantation (TACE-125iodine) in patients with hepatocellular carcinoma (HCC) and portal vein tumor thrombus (PVTT) in the first-order portal vein branch.Materials and Methods The medical records of consecutive patients with HCC and PVTT who received TACE-125iodine or TACE alone,between January 2009 and December 2011 were retrospectively evaluated.In the TACE-125iodine group,125iodine implantation was performed 4-7 days after the first TACE session.Outcomes of the groups were compared using the t-test and Kaplan-Meier method based on the repeated TACE procedure,PVTT responses,and median survival.Results Fifty patients received TACE-125iodine,and 50 received TACE alone.TACE-125iodine showed a significant survival benefit compared to TACE alone in patients with PVTT (median survival,13.1 vs.6.0 months;P<0.01).Moreover,the PVTT control rate was significantly higher in the TACE-125iodine group (78% vs.18%;P<0.01).On multivariate analysis,TACE-125iodine treatment was an independent prognostic factor for overall survival.The bilirubin level increased at 4 weeks but recovered at 8 weeks,with no difference from baseline.There were no severe adverse events occurred related to 125iodine seed implantation.Conclusion TACE-125iodine therapy may be effective for patients with advanced HCC who develop a tumor thrombus in the first-order portal vein branches.In patients with unresectable HCC who develop PVTT,TACE-125iodine treatment may prolong survival,with minimal adverse events.
Hepatocellular Carcinoma Portal Vein Tumor Thrombus Transarterial Chemoembolization 125Iodine Implantation
Jun Peng LUO Hong LU
Department of Cancer, The Affiliated HuaiHe Hospital of Henan University / 8 Baogong Road, Kaifeng, Henan Province, P.R.China, 475000
国内会议
第六届中国肿瘤绿色治疗新技术论坛、第四届老年肿瘤内科规范化诊治及新进展研讨会
郑州
英文
331-340
2016-11-04（万方平台首次上网日期，不代表论文的发表时间）